منابع مشابه
IL-21/IL-21R in Autoimmune Diseases
Interleukin-21 (IL-21), the member of the γ-chain-related cytokine family, and its receptor (IL-21R), has been evidenced involving in the immune response, resulting in the development of autoimmune diseases, infectious diseases and tumors. This short communication reviews an overall outline of its genetic variants and expression in autoimmune diseases. It focuses on a series of recent studies t...
متن کاملIL-21 and Sjögren's syndrome
Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary glands. The known functions of IL-21 in facilitating differentiation, proliferat...
متن کاملIL 21 R ( interleukin 21 receptor )
The IL21R gene is comprised of 9 exons (+2 alternative first exons), spanning 48.4kb on chromosome 16p11 (Parrish-Novak, 2000). The human IL21R promoter region, contained within nucleotides -789 to +195 (relative to the start of exon 1a) induces the high levels of transcription in reporter assays (Ueda, 2002). A critical SP1 binding site is contained in the region from -80 to -20 and is essenti...
متن کاملWork-Related physical activity and coronary diseases
Introduction: Prevalence of cardiovascular disease (CVD) is increasing in the world. Modernization and reduction of physical activity in present century and also controversial results about relationship between work-related physical activity and CVD, lead to investigate the relationship between work-related physical activity and CVD. Methods: This cross-sectional study is based on data from f...
متن کاملIL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) ex...
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ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2011
ISSN: 2155-9899
DOI: 10.4172/2155-9899.s1-008